Efficacy and Safety of a Topically Applied AvÀne Spring Water Spray in the Healing of Facial Skin after Laser Resurfacing

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Efficacy and Safety of a Topically Applied AvÀne Spring Water Spray in the Healing of Facial Skin after Laser Resurfacing
Issue online:
07 Jun 2002
To cite this article: L Sulimovic MD, D Licu MD, E Ledo MD, J.M Naeyaert MD, P Pigatto MD, C Tzermias MD, J. Vasquez Doval MD, P Dupuy MD (2002)
Efficacy and Safety of a Topically Applied AvÀne Spring Water Spray in the Healing of Facial Skin after Laser Resurfacing
Dermatologic Surgery 28 (5), 415̉418.
doi:10.1046/j.1524-4725.2002.00198.x
Blackwell Synergy

L. Sulimovic, MD**Paris, , D. Licu, MD‹‹Pierre-Fabre Research Institute, Vigoulet;, E. Ledo, MD··Madrid, , J.M. Naeyaert, MD??Gent, , P. Pigatto, MD****Milan, , C. Tzermias, MD******AthÀnes, , J. Vasquez Doval, MD********Pamplone. and P. Dupuy, MD‹‹Pierre-Fabre Research Institute, Vigoulet;

Address correspondence and reprint requests to: P. Dupuy, MD, Pierre-Fabre Research Institute, All»e Camille SoulảBP 74̉Vigoulet, 31322̉Castanet Tolosan Cedex (France), or E-mail: patrick.dupuy@pierre-fabre.com.

D. LICU AND P. DUPUY ARE EMPLOYEES OF PIERRE-FABRE LABORATORIES WHICH MARKETS THE TEST PRODUCT. L. SULIMOVIC, MD, E. LEDO, MD, J.M. NAEYAERT, MD, P. PIGATTO, MD, C. TZERMIAS, MD, AND J. VASQUEZ DOVAL, MD HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.

Abstract
background.Although laser resurfacing is a well-accepted treatment, tolerance problems may preclude patient's acceptance of the procedure. Post-laser protracted erythema is a prime problem, associated with the symptoms of pain, itching, stinging and tightening.

objective.The present study was conducted to evaluate a low-salt medical spring water (AvÀne, AvÀne-les-Bains, France), in conjunction with the standard use of an emollient, to improve tolerance by hydrating the postlaser skin.

methods.A controlled, randomized, open-labeled, multicentric and two parallel group study was completed after 84 days in 74 patients, 34 applying a petrolatum ointment alone (control group), and 40 applying petrolatum ointment in association with the AvÀne spring water spray ad libitum (water group).

results.The water spray showed a pronounced effect on reducing erythema, from the second week of postlaser onwards, with a statistically significant difference in favor of the water group compared with the control group (p &#8804; 0.04 from day 14 to day 84, except a non-significant trend on day 28). In addition, the water spray was found to significantly reduce itching on day 28 (p < 0.05), and stinging and tightening on day 14 and day 21 (p < 0.05). Pain was not modified by the water.

conclusion.Topical water appears to be a helpful adjunctive treatment to petrolatum ointment for counteracting erythema, itching, stinging and tightening during the postlaser treatment period.

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