Thermal responses of ex vivo human skin during multiple cryogen spurts and 1,450 nm laser pulses

Thermal responses of ex vivo human skin during multiple cryogen spurts and 1,450 nm laser pulses
January 2006
Rong Zhang, PhD 1 *, Julio C. Ramirez-San-Juan, PhD 1 2, Bernard Choi, PhD 1, Wangcun Jia, PhD 1, Guillermo Aguilar, PhD 3, Kristen M. Kelly, MD 1 4, J. Stuart Nelson, MD, PhD 1 4
1Beckman Laser Institute, University of California, Irvine, California 92612
2Departamento de Optica, Instituto Nacional de Astrofisica, Optica y Electronica, Puebla, Mexico
3Department of Mechanical Engineering, University of California, Riverside, California 92521
4Department of Dermatology, University of California, Irvine, California 92612
Lasers in Surgery and Medicine

Abstract

Background and Objective
Although cryogen spray cooling (CSC) is used to minimize the risk of epidermal damage during laser dermatologic surgery, concern has been expressed that CSC may induce cryo-injury. The objective of this study is to measure temperature variations at the epidermal-dermal junction in ex vivo human skin during three clinically relevant multiple cryogen spurt - laser pulse sequences (MCS-LPS).

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