Thickness of Healthy and Affected Skin of Children with Port Wine Stains: Potential Repercussions on Response to Pulsed Dye Laser Treatment

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Thickness of Healthy and Affected Skin of Children with Port Wine Stains: Potential Repercussions on Response to Pulsed Dye Laser Treatment
December 2004
To cite this article: Eduardo Nagore, Celia Requena, Amparo Sevila, Joaquim Coll, Dolors Costa, Rafael Botella-Estrada, Onofre Sanmartin, Carlos Serra-Guill»n, Carlos Guill»n (2004)
Thickness of Healthy and Affected Skin of Children with Port Wine Stains: Potential Repercussions on Response to Pulsed Dye Laser Treatment
Dermatologic Surgery 30 (12p1), 1457Ò1461.
doi:10.1111/j.1524-4725.2004.30503.x

Eduardo Nagore**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , Celia Requena**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , Amparo Sevila**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , Joaquim CollLaboratorios Isdin, Barcelona, Spain, Dolors CostaLaboratorios Isdin, Barcelona, Spain, Rafael Botella-Estrada**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , Onofre Sanmartin**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , Carlos Serra-Guill»n**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and , and Carlos Guill»n**Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and *Department of Dermatology, Instituto Valenciano de OncologÃa, Valencia; and Laboratorios Isdin, Barcelona, Spain
Address correspondence and reprint requests to: Eduardo Nagore, Avda. Bar€n de C?rcer, 42-17a, 46002 Valencia, Spain, or e-mail: eduyame@meditex.es.
ISDIN LAB LOANED THE ULTRASONOGRAPHY EQUIPMENT FOR THIS ARTICLE.

Abstract
Background. Response of port wine stain to pulsed dye laser therapy is variable and dependent on treatment settings used and anatomic site as well as on size and depth of ectatic vessels.

Objective. Our purpose was to evaluate skin thickness in different anatomic areas and in port wine stain to thus assess its possible role in the response to pulsed dye laser.

Materials and methods. Twenty-one children with port wine stain underwent high-frequency ultrasound evaluation (20 MHz). Eighteen unaffected areas were considered in each patient and an additional measure was taken from the symmetric affected skin when present (50 areas).

Results. Skin was thicker in the centrofacial area, dermatome V1 (followed by dermatome V2, dermatome V3, and dermatomes C1-2), and with increasing age. No substantial difference between affected and symmetric nonaffected skin was found.

Conclusion. Thicker cutaneous areas fit with those that typically respond worse to pulsed dye laser. Differences in skin thickness related to age support the fact that better responses are achieved in younger patients.

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